BIOBIOBio Protocol$0.033490-3.96%
24h High$0.04
24h Low$0.03
Volume$4.0M
Updated16:43 UTC
Modelv6.2 Pythia
Backtests / BIO
OMNISCIUS · V6.2 (PYTHIA)

BIO Bio Protocol (BIO) Backtest

We ran a full walk-forward backtest using the AlgoZilla Omniscius v6.2 Pythia model for BIO - Bio Protocol. The results below cover the complete out-of-sample window from May 2025 → May 2026 across 3 walk-forward cycles (= train on the past, test exclusively on unseen future bars, then roll the window). The model executed 402 trades in total, compounding an initial $10,000 base to a final value of $25,410. All results are net of trading fees based on Bitvavo rates (0.15% entry + 0.25% exit). The model uses a 15‑minute delay on every signal to simulate live execution latency — the same decision logic runs in production.

Model v6.2 (Pythia) 3 Walk-Forward Cycles May 2025 – May 2026 $0.033490 (-3.96%)
Walk-forward validated Backtest = Live (bit-identical) Net of fees (0.15% / 0.25%) Forward-look-bias audited

Bio Protocol (BIO) is a decentralized platform that funds and coordinates biotech research through DAO-based "BioDAOs". Users participate in scientific governance, fund early-stage drug discovery, and share in the upside of breakthroughs. The token gained traction in late 2024 as a leading "DeSci" project. Lower-cap with newer history, our model treats BIO under marginal-history confidence.

Performance Overview

Key risk-adjusted metrics from the walk-forward backtest. A Sharpe above 3.0 and a profit factor above 1.5 mean winners decisively outweigh losers — by design the model wins on size, not on frequency.

Sharpe Ratio
2.46
Sortino Ratio
4.17
Profit Factor
1.65
Calmar Ratio
17.85
Win Rate
36.0%
Max Drawdown
-11.1%
Avg Drawdown
-9.19%
Alpha vs B&H
-13,049,091.1pp
Total Trades
134
Exposure
47.8%
Beats B&H
2/3
Sharpe Trend
-2.14
BIO

BIO Monthly Returns

Year Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec Year Σ
2025
+63.4%
46t
+12.3%
35t
+17.9%
37t
+59.1%
48t
-1.3%
32t
+42.2%
32t
+8.4%
25t
+11.5%
19t
+484.0%
2026
-7.2%
32t
+53.1%
34t
-4.2%
25t
+17.8%
12t
-1.7%
25t
+57.7%

Derived from the walk-forward trade log. Cells link to the matching paper-trade page when available. Color intensity = magnitude.

Smart Insights
  • Exceptional return: +154.1% — compound across the full walk-forward window.
  • Low win rate: 36.0% — profits depend on a few large winners.
  • Robust sample: 134 trades smooth out single-trade luck.
  • Strongest regime: BULL — avg +2.61% on 30 trades, WR 50%.
  • Weakest regime: CRASH — avg -0.47% on 172 trades, WR 20%.

Equity Curvev6.2 Pythia

Cumulative portfolio growth on a logarithmic scale. Each cycle starts at 1x. A smooth, upward-sloping curve indicates consistent compounding with controlled drawdowns.

Price & trade markers

1H candles for BIO over the latest walk-forward cycle (2026-01-17 → 2026-05-20) with every entry () and exit ( profitable, loss). Older cycles are summarized in the per-cycle table below.

Loading 1H candles…
Entry Profit exit Loss exit Powered by TradingView Lightweight Charts

Regime Breakdownv6.2 Pythia

Performance segmented by market condition. The model adapts entry thresholds, position sizing, and exit timing to each regime. Consistent profitability across all regimes demonstrates true robustness.

Regime Trades Win Rate Avg PnL Profit Factor Avg Bars
BULL 30 48.7% +2.39% 4.52 16.5
BEAR 148 49.0% +1.36% 2.95 14.7

Per-Cycle Resultsv6.2 Pythia

Each cycle is an independent out-of-sample test period aligned with a Bitcoin halving cycle. The model is trained on earlier cycles and tested on the next — never seeing the test data during training.

Cycle Period Sharpe Return MaxDD Win Rate Trades B&H
1 May '25 – Sep '25 3.56 68% -11.1% 38.9% 185 No
2 Sep '25 – Jan '26 2.40 27% -6.9% 35.0% 103 Yes
3 Jan '26 – May '26 1.41 19% -9.6% 34.2% 114 Yes

Trade Logv6.2 Pythia

Most recent 50 trades from the walk-forward backtest (Mar 2026 – May 2026).

Entry Exit Entry Price Exit Price PnL Regime Bars Exit Reason
20 May 2026 05:00 20 May 2026 12:00 $0.03550 $0.03520 -1.46% NEUTRAL 8 stop
19 May 2026 23:00 20 May 2026 04:00 $0.03380 $0.03540 +4.31% BEAR 6 exit_fp
19 May 2026 19:00 19 May 2026 22:00 $0.03470 $0.03440 -1.46% CRASH 4 stop
19 May 2026 03:00 19 May 2026 18:00 $0.03650 $0.03620 -1.46% BEAR 16 stop
18 May 2026 20:00 19 May 2026 01:00 $0.03830 $0.03790 -1.46% BEAR 6 stop
17 May 2026 17:00 18 May 2026 17:00 $0.03820 $0.03780 -1.46% NEUTRAL 25 stop
17 May 2026 13:00 17 May 2026 16:00 $0.03930 $0.03890 -1.46% BEAR 4 stop
16 May 2026 10:00 17 May 2026 12:00 $0.03970 $0.03930 -1.46% NEUTRAL 27 stop
16 May 2026 04:00 16 May 2026 07:00 $0.04150 $0.04110 -1.46% BEAR 4 stop
15 May 2026 23:00 16 May 2026 03:00 $0.04190 $0.04150 -1.46% BEAR 5 stop
15 May 2026 14:00 15 May 2026 22:00 $0.04260 $0.04220 -1.46% NEUTRAL 9 stop
15 May 2026 06:00 15 May 2026 13:00 $0.04280 $0.04240 -1.46% BEAR 8 stop
15 May 2026 03:00 15 May 2026 05:00 $0.04510 $0.04470 -1.46% NEUTRAL 3 stop
13 May 2026 14:00 13 May 2026 17:00 $0.04390 $0.04560 +3.45% NEUTRAL 4 signal
13 May 2026 07:00 13 May 2026 13:00 $0.04520 $0.04480 -1.46% NEUTRAL 7 stop
09 May 2026 07:00 09 May 2026 16:00 $0.05110 $0.05430 +5.83% BULL 10 exit_fp
07 May 2026 22:00 08 May 2026 16:00 $0.04540 $0.04940 +8.37% BULL 19 exit_fp
06 May 2026 21:00 07 May 2026 00:00 $0.04790 $0.04820 +0.21% NEUTRAL 4 signal
06 May 2026 15:00 06 May 2026 19:00 $0.04820 $0.04770 -1.46% BEAR 5 stop
06 May 2026 13:00 06 May 2026 14:00 $0.04910 $0.04860 -1.46% NEUTRAL 2 stop
04 May 2026 11:00 04 May 2026 12:00 $0.05870 $0.05810 -1.46% BULL 2 stop
03 May 2026 09:00 03 May 2026 13:00 $0.05370 $0.05650 +4.78% NEUTRAL 5 signal
03 May 2026 03:00 03 May 2026 08:00 $0.05510 $0.05460 -1.46% BULL 6 stop
02 May 2026 18:00 03 May 2026 01:00 $0.05640 $0.05590 -1.46% BULL 8 stop
02 May 2026 01:00 02 May 2026 03:00 $0.04280 $0.04240 -1.46% BULL 3 stop
29 Apr 2026 04:00 29 Apr 2026 07:00 $0.03320 $0.03290 -1.46% BEAR 4 stop
28 Apr 2026 08:00 28 Apr 2026 10:00 $0.02790 $0.03080 +9.94% NEUTRAL 3 signal
27 Apr 2026 22:00 28 Apr 2026 07:00 $0.02820 $0.02790 -1.46% BEAR 10 stop
24 Apr 2026 02:00 24 Apr 2026 07:00 $0.03090 $0.03360 +8.29% BEAR 6 exit_fp
20 Apr 2026 06:00 20 Apr 2026 09:00 $0.02690 $0.02700 -0.04% CRASH 4 signal
19 Apr 2026 18:00 20 Apr 2026 04:00 $0.02830 $0.02800 -1.46% CRASH 11 stop
18 Apr 2026 11:00 18 Apr 2026 19:00 $0.02730 $0.02900 +5.79% CRASH 9 signal
18 Apr 2026 01:00 18 Apr 2026 09:00 $0.02870 $0.02840 -1.46% CRASH 9 stop
11 Apr 2026 13:00 13 Apr 2026 02:00 $0.01760 $0.01740 -1.46% BEAR 38 stop
11 Apr 2026 10:00 11 Apr 2026 12:00 $0.01780 $0.01760 -1.46% CRASH 3 stop
02 Apr 2026 04:00 03 Apr 2026 05:00 $0.01630 $0.01660 +1.42% BEAR 26 signal
01 Apr 2026 02:00 01 Apr 2026 06:00 $0.01670 $0.01690 +0.78% CRASH 5 signal
30 Mar 2026 10:00 31 Mar 2026 07:00 $0.01660 $0.01680 +0.79% CRASH 22 signal
30 Mar 2026 07:00 30 Mar 2026 09:00 $0.01690 $0.01670 -1.46% CRASH 3 stop
29 Mar 2026 13:00 30 Mar 2026 02:00 $0.01600 $0.01650 +2.70% BEAR 14 exit_fp
29 Mar 2026 00:00 29 Mar 2026 12:00 $0.01620 $0.01600 -1.46% CRASH 13 stop
27 Mar 2026 14:00 28 Mar 2026 23:00 $0.01670 $0.01650 -1.46% BEAR 34 stop
27 Mar 2026 08:00 27 Mar 2026 13:00 $0.01750 $0.01730 -1.46% CRASH 6 stop
26 Mar 2026 05:00 27 Mar 2026 07:00 $0.01780 $0.01760 -1.46% BEAR 27 stop
23 Mar 2026 08:00 26 Mar 2026 01:00 $0.01820 $0.01800 -1.46% CRASH 66 stop
22 Mar 2026 00:00 23 Mar 2026 07:00 $0.01910 $0.01890 -1.46% CRASH 32 stop
20 Mar 2026 07:00 21 Mar 2026 23:00 $0.01990 $0.01970 -1.46% CRASH 41 stop
19 Mar 2026 07:00 20 Mar 2026 06:00 $0.02030 $0.02010 -1.46% BEAR 24 stop
18 Mar 2026 14:00 19 Mar 2026 06:00 $0.02150 $0.02130 -1.46% CRASH 17 stop
18 Mar 2026 00:00 18 Mar 2026 06:00 $0.02220 $0.02290 +2.73% BEAR 7 signal

Start Trading Bio Protocol Smarter

These backtest results demonstrate what our model can do. Get real-time BIO signals delivered to your Telegram with every entry, stop-loss, and take-profit.

36.0% Win Rate Sharpe 2.46 134 Trades -11.1% Max Drawdown